422 Surfactant Implementation in Treatment of Respiratory Distress Syndrome - Our Experiences

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Surfactant treatment for acute respiratory distress syndrome.

OBJECTIVE To determine prospectively the efficacy of surfactant in acute respiratory distress syndrome. STUDY DESIGN Twenty patients, 1 month to 16 years of age, diagnosed with an acute pulmonary disease with severe hypoxaemia (PaO2/FiO2 < 100) (13 with systemic or pulmonary disease and seven with cardiac disease) were treated with one to six doses of 50-200 mg/kg of porcine surfactant admini...

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Surfactant Function in Adult Respiratory Distress Syndrome*

W e have reported previously on abnormalities of human surf actant in a lung from a patient with the adult respiratory distress syndrome (ARDS) following trauma and shock.’ The lung with ARDS was compared to three normal lungs obtained from transplant donors. An abnormal static pressure-volume curve indicated reduced compliance and abnormally high surfactant film compressibility was found, but ...

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Natural surfactant substitution in respiratory distress syndrome.

Natural surfactants consist of unique proteins and lipids. Their effectiveness in improving subnormal lung function in surfactant deficiency should be established prior to any clinical trials. Rigorous tests are required to document batch to batch variability in surface activity and to exclude toxic contaminants. Up to this date randomized clinical trials in small preterm infants have demonstra...

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Neonatal Respiratory Distress Syndrome and Its Treatment with Artificial Surfactant

Neonatal respiratory distress syndrome [4], previously called hyaline membrane disease, is a respiratory disease affecting premature newborns. Neonatal respiratory distress syndrome [4] involves shallow breathing, pauses between breaths that last a few seconds, or apnea, and a bluish tinge to the infant?s skin. The syndrome occurs when microscopic sacs called alveoli in infant lungs do not prod...

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Neonatal Respiratory Distress Syndrome and Its Treatment with Artificial Surfactant

Neonatal respiratory distress syndrome [4], previously called hyaline membrane disease, is a respiratory disease affecting premature newborns. Neonatal respiratory distress syndrome [4] involves shallow breathing, pauses between breaths that last a few seconds, or apnea, and a bluish tinge to the infant?s skin. The syndrome occurs when microscopic sacs called alveoli in infant lungs do not prod...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2012

ISSN: 0003-9888,1468-2044

DOI: 10.1136/archdischild-2012-302724.0422